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ADR Term
ADReCS ID
MedDRA Code
MeSH ID
Drug Name
Drug ID
ATC Code
DrugBank ID
KEGG ID
PubChem ID
CAS RN
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ADR Ontology
ADR Term
Hepatotoxicity
ADR ID
BADD_A02053
ADR Hierarchy
09
Hepatobiliary disorders
09.01
Hepatic and hepatobiliary disorders
09.01.07
Hepatocellular damage and hepatitis NEC
09.01.07.009
Hepatotoxicity
12
Injury, poisoning and procedural complications
12.03
Exposures, chemical injuries and poisoning
12.03.01
Poisoning and toxicity
12.03.01.008
Hepatotoxicity
Description
Not Available
MedDRA Code
10019851
MeSH ID
Not Available
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Not Available
Synonym
Hepatotoxic effect | Hepatotoxicity | Hepatotoxicity aggravated | Hepatotoxicity NOS | Toxaemia of liver | Toxemia of liver | Toxic acute liver disease
ADR Related Proteins
Protein Name
UniProt AC
TTD Target ID
Alanine aminotransferase 1
P24298
Not Available
Alanine aminotransferase 1
Q8QZR5
Not Available
Albumin
P02768
T63068
Albumin
P02770
Not Available
Alkaline phosphatase, placental type
P05187
Not Available
Alkaline phosphatase, tissue-nonspecific isozyme
P05186
T09538
Alpha-fetoprotein
P02771
T10828
Aspartate aminotransferase, mitochondrial
P05202
Not Available
ATP-binding cassette subfamily B member 1A
Q9JK64
Not Available
Beta-2 adrenergic receptor
P07550
T52522
Caspase recruitment domain-containing protein 10
Q9BWT7
Not Available
Catalase
P04762
Not Available
Cholinesterase
P06276
T99799
Cytochrome P450
Q14097
Not Available
Cytochrome P450 1A1
P04798
Not Available
Cytochrome P450 1A2
P05177
Not Available
Cytochrome P450 2A6
P11509
T06455
Cytochrome P450 2C19
P33261
Not Available
Cytochrome P450 2C9
P11712
T19244
Cytochrome P450 2D6
P10635
T57392
Cytochrome P450 2E1
P05181
Not Available
Cytochrome P450 2E1
Q05421
Not Available
Cytochrome P450 3A4
P08684
T37848
Diazepam-binding inhibitor-like 5
P56702
Not Available
Fibroblast growth factor 4
P08620
T28076
Glucocorticoid receptor
P04150
T40016
Glutathione peroxidase 1
P04041
Not Available
L-lactate dehydrogenase A chain
P00338
T15053
Metallothionein-1A
P04731
Not Available
Myeloperoxidase
P05164
T23471
Myeloperoxidase
P11247
Not Available
N-alpha-acetyltransferase 20
P61599
Not Available
Nitric oxide synthase, inducible
Q06518
Not Available
Omega-amidase NIT2
Q9JHW2
Not Available
Ornithine decarboxylase
P11926
T60366
Solute carrier family 12 member 3
P55017
T84886
Sorbitol dehydrogenase
Q00796
T59445
Superoxide dismutase [Cu-Zn]
P07632
Not Available
Transcription factor Jun
P05412
T69085
Transforming protein v-Fos/v-Fox
P29176
Not Available
Tumor necrosis factor
P06804
Not Available
Tumor necrosis factor
P16599
Not Available
Tyrosine aminotransferase
P17735
Not Available
UDP-glucuronosyltransferase 1-6
P19224
Not Available
UDP-glucuronosyltransferase 1A1
P22309
T93480
UDP-glucuronosyltransferase 1A9
O60656
Not Available
UDP-glucuronosyltransferase 2B15
P54855
Not Available
Drugs Leading to the ADR
Drug ID
Drug Name
ADR Frequency (FAERS)
ADR Severity Grade (FAERS)
BADD_D00221
Bedaquiline
0.103298%
BADD_D00222
Bedaquiline fumarate
-
-
BADD_D00225
Belinostat
-
-
BADD_D00271
Bicalutamide
0.006444%
BADD_D00284
Bortezomib
-
-
BADD_D00285
Bosentan
-
-
BADD_D00286
Bosutinib
0.001598%
BADD_D00287
Bosutinib monohydrate
-
-
BADD_D00312
Bupropion
-
-
BADD_D00330
Cabozantinib
0.002931%
BADD_D00347
Candesartan cilexetil
0.003855%
BADD_D00349
Capecitabine
0.003996%
BADD_D00356
Carbamazepine
-
-
BADD_D00364
Carboplatin
-
-
BADD_D00367
Carfilzomib
-
-
BADD_D00371
Carmustine
-
-
BADD_D00376
Caspofungin
0.001410%
BADD_D00377
Caspofungin acetate
-
-
BADD_D00405
Ceftriaxone
0.051065%
BADD_D00410
Celecoxib
-
-
BADD_D00414
Ceritinib
0.000799%
BADD_D00417
Cetirizine
0.000729%
BADD_D00429
Chlorambucil
0.000533%
BADD_D00467
Cimetidine
-
-
BADD_D00474
Cisplatin
0.002398%
BADD_D00475
Citalopram
-
-
BADD_D00479
Cladribine
0.000730%
BADD_D00480
Clarithromycin
0.001645%
BADD_D00495
Clofarabine
0.000533%
BADD_D00504
Clopidogrel
-
-
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